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KMID : 0383819870340030233
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Tuberculosis and Respiratory Diseases
1987 Volume.34 No. 3 p.233 ~ p.239
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The Effect of H2-Receptor Blocker, Ranitidine, on the Theophylline Metabolism
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주순기/Soon Ki Joo
이윤우/유홍옥/이정형/김동순/Yoon Woo Lee/Hong Ok Ryoo/Jeong Hyeong Lee/Dong Soon Kim
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Abstract
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Because of the increased incidence of peptic ulcer disease in patients with chronic
obstructive pulmonary disease (COPD), sometimes it is necessary to use Ha·blocking
agents and aminophylline at the same time. Among the H2-blockers,
cimetidine is well known to impair the theophylline metabolism. But there are some
controversies about the effect of ranitidine on the metabolism of theophylline. So we
have done the pharmacokinetic studies of aminophylline with and without ranitidine on 6
normal subjects and also measured the serum aminophylline levels following the
administration of ranitidine for 7 days on 9 patients with COPD. In 6 normal subjects,
serum theophylline levels were measured at 1/2 hour,2 hours, 4 hours, 6 hours and 8
hours after the infusion of 7 ㎎/㎏ of aminophylline. The serum theophylline levels were
measured again after the subjects took 300 ㎎/day ranitidine for 4-7 days. There were
no significant differences in serum theophylline levels between pre- and post-ranitidine
administration.
Also no significant differences were found with and without ranitidine in β
(elimination rate constant: 0.0803±0.0143 hr-1 vs 0.0737±0.0125
hr-), Tl/2(elimination half life: 8.91±1.79 hours vs 9.64±1.64 hours), A.U.C
(area under the time concentration curve: 184.37 ± 32.07 ug/㎖/hr vs 189.67±22.77 ㎍/㎖
/hr), M.R.T (mean residence time: 11.88± 2.85 hours vs 12.88 ± 2.78 hours), Vd
(volume of distribution: 0.49±0.06 L/㎏ vs 0.52±0.08 L/㎏) and C.L. (clearance: 2.52±
0.40 L/㎏ vs 2.43±0.29 L/㎏).
In 9 patients with COPD, serum trough levels of theophylline were compared before
and after taking ranitidine for 7 days. Again no significant effects of ranitidine on the
theophylline level were found (10.5± 2.6 ng/㎖ vs 10.0± 2.5 ng/㎖). Our data suggest
that ranitidine does not have significant effect on the aminophylline metabolism.
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